Mamelodi Sundowns will face off with Bloemfontein Celtic in the 2020 MTN8 quarter-final match at Lucas Moripe Stadium on Sunday.
Masandawana are looking to keep the momentum going having won the last three domestic trophies, PSL title, Nedbank Cup and Telkom Knockout under the now-departed coach Pitso Mosimane.
Newly-appointed Sundowns co-coaches Manqoba Mngqithi and Rhulani Mokwena will be keen to start their reign with a win over a wounded Celtic side.
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Siwelele will be seeking revenge after losing to Sundowns in the 2020 Nedbank Cup final last month, and they are hoping to end their eight-year wait for a major trophy having won their last title in 2012 which was the Telkom Knockout.