A tantalising trip to Stamford Bridge to face Chelsea will await Liverpool if they defeat Shrewsbury Town, while Wayne Rooney could be poised for a reunion with Manchester United following the FA Cup fifth-round draw.
The Champions League holders must overcome a replay at Anfield following their 2-2 draw with the Shrews on Sunday while ex-Red Devils favourite Rooney must guide Derby County past a rematch with Northampton Town first.
Holders Manchester City meanwhile will face a trip to Sheffield Wednesday, while Norwich City have set up an all-Premier League tie against the winners of Southampton and Tottenham's replay.