Middendorp's side will be looking to stretch their lead at the top of the PSL standings with a win over the Chilli Boys
Kaizer Chiefs travel to Port Elizabeth to take on Chippa United in what will be their 10th league game of the season.
Amakhosi head into the encounter on the back of a morale-boosting penalty shoot-out win over Orlando Pirates last weekend.
Chippa United, on the other hand, held Mamelodi Sundowns before losing on penalties on Sunday afternoon.
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Ernst Middendorp has already spoken about the importance of focusing on the Chilli Boys without worrying about the upcoming Soweto Derby.