Old and young join together with Mexico's all-time leading goalscorer Javier "Chicharito" Hernandez set to line up between 18-year-old Diego Lainez and 20-year-old Roberto Alvarado for El Tri in Tuesday's match against Paraguay.
The 30-year-old West Ham United forward enters Tata Martino's overhauled starting XI, with the manager making 10 changes from Friday's 3-1 victory over Chile. Edson Alvarez, the Club America central midfielder, is the only player to keep his place from Martino's debut.
Alvarez will be joined in the midfield by Erick Gutierrez, who came on in the 75th minute of last week's match, and LA Galaxy midfielder Jonathan dos Santos, who is seeing his first minutes of the Martino era.