The rematch of the 2015 FIBA Americas Women's Championship turned into a showcase for a new-look Canadian roster.
UConn's Kia Nurse had six points and rebounds in 15 minutes while former UCLA star Nirra Fields led three players in double figures with 18 points as defending champion Canada opened the FIBA AmeriCup event with a surprisingly routine 81-35 win over Cuba.
Ruth Hamblin had 15 points and 10 rebounds while Jamie Scott added 12 points for Canada.
Anisleidy Galindo had 12 points and four steals for Cuba.
Canada plays Puerto Rico on Monday. Manchester's Ashley Perez had seven points, four rebounds and two steals as Puerto Rico opened the tournament with a 69-49 win over Mexico.