The two-vehicle accident occurred around 12:30 p.m., near Coogan Bvld., closing down the street for several hours as the scene was investigated.
Mystic River Ambulance transported the two sole operators, 19-year-old Ryan Brown of Mystic and Michelle L. McMullen, 52, of Norwich, to L&M hospital, police said. McMullen was pronounced deceased soon after, police added.
The investigation remains ongoing and no further information was released about the events leading up to the accident.