Marlon Mack and Quinton Flowers rushed for a combined four touchdowns as USF powered past UCF 48-31 in Tampa.
USF totaled 503 yards in the game with 351 coming on the ground with Mack and Flowers both rushing for over 150 yards.
The Knights finished with 402 total yards and 338 yards through the air.
UCF turned the ball over three times, including a fumble in the first quarter that USF recovered for a touchdown.
The Bulls entered game seventh in the country in scoring offense, averaging 43.2 points per game.
USF has won the rivalry game two straight times and leads the all-time series 6-2.