Tulane ended its past season 3-9 American Athletic Conference, and is currently 0-1 AAC after losing its season opener to Wake Forest 7-3 Atlantic Coast Conference. Southern is also 0-1 ACC, falling to the University of Louisiana Monroe 38-21 in its first game of the season. Southern finished the 2015 season with a 6-5, 6-3 Southwestern Athletic Conference record.
This is the first time Southern will face the Wave in Yulman Stadium. In their two previous match-ups, the two Pelican state teams competed at the Mercedes-Benz Superdome. The Green Wave will enter its third game against Southern with a 2-0 record.