Wolves striker Raul Jimenez could make his first competitive appearance at Molineux in nine months after returning from a fractured skull last weekend.
Defensive duo Yerson Mosquera and Willy Boly remain out with hamstring injuries.
Tottenham must decide whether to start Harry Kane, who is yet to feature this season as he continues to be linked to Manchester City.
A host of regulars are set to return following the midweek European defeat.
LAWRO'S PREDICTION
This is a very early return to Molineux for Spurs boss Nuno Espirito Santo, and I think his old team will cause his new one a few problems.