Wolves midfielder Leander Dendoncker, who was injured against Chelsea and missed Monday's defeat at Burnley, is a major doubt for this game.
Defender Jonny and forward Raul Jimenez remain long-term injury absentees.
Tottenham boss Jose Mourinho is set to shuffle his pack after making seven changes for Wednesday's EFL Cup win.
Giovani Lo Celso is out with a hamstring injury but Tanguy Ndombele is fit despite not making the squad for the midweek trip to Stoke.
Defender Japhet Tanganga is out until the new year with a shoulder problem.
MATCH FACTS
Head-to-head
- Five of the last six meetings have been won by the away side, with Tottenham's 3-1 win in 2010 the last victory earned by the home team.