The France international moved to Spurs from Newcastle in the summer after they shelled out £30million.
However since the switch the 27-year-old has failed to hit the ground running and he was let out of Tottenham's squad for their match with Chelsea last weekend.
It has led to speculation that Sissoko could be shown the door as early as January after just four months at Tottenham.
As a result Juventus and Inter Milan, according to Corriere dello Sport, are monitoring the situation in case a shock deal can be struck.
The Italian pair reportedly looked at the Frenchman in the summer and still hold an interest now.