Pedro Porro and Destiny Udogie are injured and will miss Tottenham's Premier League match with Wolves, says manager Ange Postecoglou.
Spurs' Australian boss expects Porro, 26, to be fit in a "couple of weeks" after the Spain right-back suffered a muscle strain in training.
Italy left-back Udogie, 21, has a minor knee problem.
Back-up goalkeeper Fraser Forster is also set to be on the sidelines for two months with a fractured foot.
Porro and Udogie's absences on Saturday will mark the first time this season that Spurs have started a match in the English top flight without both of their first-choice full-backs.