Tottenham have suffered a second injury blow this week after it was revealed Yves Bissouma will have surgery on Friday.
Spurs were already without captain Hugo Lloris for Saturday's trip to Leicester and Bissouma will also be absent.
The midfielder has suffered a stress fracture to his left ankle and will have surgery on Friday.
The club revealed the news on Twitter, adding: "A timeframe for his return will be determined after surgery."
It is a big blow to boss Antonio Conte, who only returned to work himself on Thursday following his own operation last week to remove his gallbladder.