Tottenham will be without Destiny Udogie and Pedro Porro, with the latter set to miss the next couple of weeks.
Captain Son Heung-min is likely to make his first start since returning from the Asian Cup, while Ryan Sessegnon and Manor Solomon remain sidelined.
Wolves are without forward Matheus Cunha, who sustained a hamstring injury during last week's defeat by Brentford.
Hwang Hee-chan is expected to fill the void left by the Brazilian after recovering from a minor calf problem.
MATCH FACTS
Head-to-head
- Wolves have won three of the past four top-flight meetings, although two of those victories have come at Molineux.