Tottenham's Cristian Romero, who played every minute of the first two games of the season, is ruled out with a muscle injury sustained against Chelsea.
Wolves could give a debut to record signing Matheus Nunes following his move from Sporting Lisbon.
Joao Moutinho returned to training this week and could make his first appearance of the season.
SUTTON'S PREDICTION
I was a bit disappointed with Tottenham's performance against Chelsea last weekend.
Spurs showed good character to come back and get a draw but that result was more to do with poor refereeing decisions and luck as far as I could see.