Tottenham captain Son Heung-min was forced off against West Ham after taking a blow to the back and will be monitored.
Seven other Spurs players are sidelined by injuries.
Newcastle boss Eddie Howe is optimistic Jamaal Lascelles will be fit despite limping off in the closing stages of the midweek defeat at Everton.
The visitors are likely to be without a dozen players, including goalkeeper Nick Pope, who could be sidelined until April.
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MATCH FACTS
Head-to-head
- Newcastle have won 11 Premier League matches away to Tottenham, a total they have only matched against West Ham.