Tottenham defender Cristian Romero has been passed fit after being forced off with a head injury against Brentford.
Rodrigo Bentancur, Fraser Forster, Bryan Gil and Ryan Sessegnon are all still unavailable.
Manchester United are expected to have Lisandro Martinez available despite him going off at half-time against Wolves on Monday.
They remain without Tom Heaton, Rasmus Hojlund, Tyrell Malacia, Kobbie Mainoo and Amad Diallo.
MATCH FACTS
Head-to-head
- Tottenham's only victory in their last nine league games against Manchester United was a 6-1 away win in October 2020.