Spurs could welcome back defenders Toby Alderweireld and Serge Aurier, who were omitted last week because they missed a Covid-19 test.
Manchester United manager Ole Gunnar Solskjaer is hopeful Luke Shaw will be fit despite his half-time withdrawal during Thursday's win in Granada.
Marcus Rashford continues to play with an ankle injury, while Anthony Martial could be out for the season.
LAWRO'S PREDICTION
When Tottenham beat Manchester United 6-1 at Old Trafford on 4 October it wasn't even the craziest result of the day - that was Villa's 7-2 win over Liverpool.