Tottenham are likely to resist rushing back defender Micky van der Ven, who is recovering from a hamstring injury.
Fraser Forster, Ryan Sessegnon and Manor Solomon remain long-term absentees.
Winger Chiedozie Ogbene joins Luton's lengthy injury list after suffering a hamstring issue on international duty.
Alfie Doughty and Pelly Ruddock Mpanzu suffered knocks in the recent draw with Nottingham Forest but should both be passed fit.
MATCH FACTS
Head-to-head
- Spurs host Luton in a competitive game for the first time since a 4-1 top-flight win at White Hart Lane in November 1991.