Tottenham pair Dejan Kulusevski and Richarlison should be available to start after building up their fitness with substitute appearances in the Carabao Cup tie at Forest on Wednesday.
Ryan Sessegnon is a major doubt with a muscle injury sustained during that game, while Son Heung-min remains out.
Leeds United will be without Patrick Bamford and Mateusz Klich.
Jack Harrison may miss out with a muscle strain and the game comes too soon for Adam Forshaw.
CHRIS SUTTON'S PREDICTION
I've really not got a clue what will happen here. Spurs boss Antonio Conte says his players are tired, yet they have this record of fighting back in games this season - so that does not really add up.