Tottenham pair Lucas Moura and Carlos Vinicius might not be fit in time to face Leeds, while Giovani Lo Celso remains absent with a hamstring injury.
Gareth Bale, who has made just one Premier League start, will be out for a few weeks with a calf strain.
Leeds midfielder Mateusz Klich will be assessed after sustaining a thigh injury during the 5-0 win at West Brom.
Liam Cooper is also a doubt with an abdominal strain and Diego Llorente is still nursing a muscle problem.
LAWRO'S PREDICTION
This is such an intriguing match because of the difference in the way both teams play, and how both managers see the game.