Tottenham Hotspur could be missing up to nine players, although Brennan Johnson should be available after he sustained a gash to his head on his return to Nottingham Forest.
Yves Bissouma begins a four-game ban, while Destiny Udogie is also suspended for one match.
Everton must assess the fitness of several players, including Seamus Coleman and Ashley Young.
Abdoulaye Doucoure and Vitaly Mykolenko are expected to remain out.
MATCH FACTS
Head-to-head
- Tottenham Hotspur have lost just one of their last 21 Premier League matches against Everton (W10, D10), a 1-0 defeat in September 2020.