Tottenham head coach Jose Mourinho is set to rotate his squad after describing Spurs' performance in the midweek Europa League defeat as poor.
Eric Dier and Tanguy Ndombele are expected to be fit after being rested for Thursday's game as a precaution.
Brighton captain Lewis Dunk is banned and forward Alireza Jahanbakhsh is out with a hamstring problem.
Midfielder Davy Propper has a slim chance of featuring after returning from an Achilles injury.
Danny Welbeck could make his first appearance for the club. He was an unused substitute for Monday's draw with West Brom.
LAWRO'S PREDICTION
Tottenham are absolutely flying at the moment and quite rightly everyone has been raving about how good the partnership is between Harry Kane and Son Heung-min up front.