Brentford striker Ivan Toney has been suspended for eight months after admitting numerous breaches of FA betting regulations.
Pontus Jansson, Keane Lewis-Potter and Christian Norgaard remain sidelined.
Spurs defenders Eric Dier and Japhet Tanganga could return after both were absent with minor issues last weekend.
Rodrigo Bentancur and Ryan Sessegnon will be available next season, while captain Hugo Lloris has played his last game for the club.
CHRIS SUTTON'S PREDICTION
Tottenham's interim head coach Ryan Mason has indicated he wants the job permanently but he hasn't done anything since taking charge which makes you think 'blimey, he can take them to the next level'.