Tottenham midfielder James Maddison could start for the first time since 6 November, having come off the bench against Manchester City.
Giovani Lo Celso, Manor Solomon and Alejo Veliz are out, while Son Heung-min, Yves Bissouma and Pape Sarr are unavailable due to international duty.
Brentford's Sergio Reguilon is ineligible to face his parent club.
Their lengthy injury list includes Rico Henry, Aaron Hickey, Bryan Mbeumo and Kevin Schade.
Saman Ghoddos, Kim Ji-soo, Frank Onyeka and Yoane Wissa are all on international duty.
However, Christian Norgaard is fit again.
MATCH FACTS
Head-to-head
- Tottenham's only defeat in their past nine league games against Brentford was by 3-1 in last season's corresponding fixture.