Spurs’ Champions League hopes are currently hanging by a thread after home defeats to Monaco and Bayer Leverkusen.
With four points from four games, a win in the south of France will give the Lilywhites a chance of qualifying for the knockout stages of the competitions.
Unfortunately, Mauricio Pochettino must do without Erik Lamela, Toby Alderweireld, and Ben Davies, who remain sidelined with injury.
And adding to that, Harry Kane, Dele Alli, and Mousa Dembele have doubts over their fitness and are all unlikely to play 90 minutes, especially ahead of a crunch clash with Chelsea on Saturday.