Antonio Conte's reign as Tottenham boss begins with the visit of Vitesse Arnhem for Thursday's Europa Conference League game.
Spurs are likely to be without Bryan Gil (hamstring) but the likes of Sergio Reguilon, Tanguy Ndombele and Dele Alli will all hope to start.
Million Manhoef is absent for Vitesse.
However, left-midfielder Maximilian Wittek could play for the first time since scoring against Spurs in the reverse fixture in Group G.
Tottenham currently sit third in their group, three points behind leaders Rennes and two points behind their Dutch opponents.
MATCH FACTS
Head-to-head
- Vitesse had never beaten an English club in a Uefa competition, or even scored a goal against them, until their victory over Tottenham in October.