Injury-hit Tottenham face losing centre-back Cristian Romero for up to five weeks with a hamstring strain, says manager Ange Postecoglou.
Defenders Micky van de Ven and Ryan Sessegnon are also out injured, while full-back Destiny Udogie is suspended for Thursday's match at Brighton.
"[It's] disappointing to lose [Romero], for sure," said Postecoglou.
"He had a scan the other day and has got a hamstring strain. We are looking at probably four or five weeks for him."
World Cup winner Romero missed three matches through suspension in November and December after being sent off in Tottenham's 4-1 home defeat to Chelsea.