Mauricio Pochettino is set to hand highly-rated defender Cameron Carter-Vickers his senior debut in the EFL Cup against Gillingham.
Sportsmail understands the 18-year-old will start against the Gills, marking his first full appearance for the club having sat on the bench for all of Tottenham's games so far this season.
The American is set to play alongside Kevin Wimmer at centre back; while right back Kieran Trippier is also set for his first appearance of the season.
Fellow youngster Harry Winks, Josh Onomah and Tom Carroll are also set to feature against the Gills, while Vincent Janssen could start in place of injured Harry Kane.