Wales defender Ben Davies has been ruled out of Tottenham Hotspur's north London derby against Arsenal in the Premier League on Sunday.
Davies suffered an ankle injury during Spurs' 1-0 defeat by Bayer Leverkusen in the Champions League on Wednesday.
The 23-year-old has been included in the Wales squad for the World Cup qualifier against Serbia on 12 November.
He has started in Wales' opening three qualifiers.