Tottenham could be without any fit centre-backs for Sunday's Premier League game against Wolves after Ben Davies suffered a setback in his recovery.
The Wales international, 31, has been out since 5 December with a hamstring injury.
Davies had been nearing a return, but manager Ange Postecoglou said on Friday: "No, he is ruled out. Unfortunately he had a setback in training, so he'll probably be out for a couple of weeks."
Radu Draguu0219in will also be assessed after he was forced off with an ankle injury in Thursday's defeat by Nottingham Forest.
If the Romanian is ruled out he would join Davies and Spurs' other centre-backs Micky van de Ven and Cristian Romero on the sidelines.