Oriol Romeu is available again after suspension for Southampton.
Jordy Clasie is out with a groin injury, while defender Matt Targett and striker Charlie Austin remain long-term absentees.
Toby Alderweireld is back for Tottenham after missing the win at Burnley with a back problem, along with Mousa Dembele.
Danny Rose has recovered from a thigh complaint and Vincent Janssen is fit again, but Erik Lamela remains out.
RADIO 5 LIVE COMMENTATOR'S NOTES
Jonathan Pearce: "Counting the cost of Christmas? The losers of this will be! A Saints defeat should rule them out of a top-six place.