Tottenham know anything less than a victory will not be enough as they bid to keep their hopes of reaching the Champions League knockout stages alive against Inter Milan.
The Italian side travel to Wembley Stadium in a strong position in Group B as they look best placed to take the runners-up spot behind leaders Barcelona, who face PSV in Eindhoven on Wednesday evening.
Elsewhere in Europe, Atletico Madrid host Monaco in the early match of the night while an in-form Borussia Dortmund take on Club Brugge, a side buoyed by the demolition of Thierry Henry's Monaco in the last outing.