Tottenham boss Nuno Espirito Santo has appealed for help from football and political authorities over red-list travel during the international break.
But Spurs pair Giovani Lo Celso and Cristian Romero are set to travel home to Argentina - a country on the list.
They would miss three Tottenham games due to UK quarantining requirements.
"We know what it means for all of the players to play for their national teams. It's something they're very proud of, so what we are trying to do is anticipate the situations," said Nuno after Sunday's win over Watford took Tottenham top of the early-season table.