Tottenham boss Antonio Conte will make changes to his side for Thursday's Europa Conference League game at Slovenian side NS Mura.
Spurs are second in Group G on seven points - three behind leaders Rennes - with two games to go.
The group winners will go through automatically and the runners-up will play a two-legged play-off in February.
"For us this competition is important. We want to take this fixture seriously," said Conte.
Tottenham have not won a trophy since 2008.
Before he was sacked as manager this month, Nuno Espirito Santo rested his first-choice XI for the defeat at Vitesse Arnhem.