Midway through the first half and Marcel Sabitzer accelerated ahead of Japhet Tanganga and beat Hugo Lloris for the second time on the night.
One down in the tie had become three down in what seemed to be a blink of the eye, the Red Bull cans were shaken and cracked open and Julian Nagelsmann was aiming his electric skateboard towards the Champions League quarter finals.
For Tottenham, the second goal scored by Leipzig captain Sabitzer was the 37th they had let in since Jose Mourinho arrived on the scene at the end of November.