Manchester United forward Marcus Rashford dropped out of the starting line-up against Newcastle following illness but could return on Wednesday.
United will monitor Christian Eriksen, who was too unwell to feature on Sunday, while Scott McTominay returns from suspension.
Anthony Martial remains unavailable because of a back problem.
Dejan Kulusevski is again doubtful for Tottenham because of a niggling hamstring issue.
Emerson Royal serves the final game of a three-match ban, while Richarlison is likely to be out for two weeks with a calf injury.
CHRIS SUTTON'S PREDICTION
Manchester United rode their luck against Newcastle but I think it will be a different story against Spurs.