Manchester United forward Cristiano Ronaldo is fit again after missing last weekend's derby defeat with a hip issue.
Defender Raphael Varane returns after a spell out with Covid-19, while Edinson Cavani is also available.
Midfielder Scott McTominay is struggling with a calf issue, while left-back Luke Shaw remains out.
Tottenham are without wing-back Ryan Sessegnon, who suffered a hamstring injury during the 5-0 win over Everton.
Oliver Skipp and Japhet Tanganga stay sidelined with respective groin and knee problems.
LAWRO'S PREDICTION
Manchester United were decent in the first half at the Etihad Stadium on Sunday because they carried a threat but what we saw from them after that was basically a capitulation.