Manchester United defender Eric Bailly could make his first league appearance since October after returning from injury in Thursday's Europa League win.
Chris Smalling and Luke Shaw remain out, but Michael Carrick and Antonio Valencia are in contention after being rested for the trip to Ukraine.
Tottenham's Toby Alderweireld should be involved after making his comeback from a knee injury against CSKA Moscow in midweek.
Ben Davies and Vincent Janssen are out.
MOTD COMMENTATOR'S NOTES
Guy Mowbray: "United used to have such dominance over Spurs that Sir Alex Ferguson's pre-match team talk consisted of three words: 'Lads, it's Tottenham'!