Forward Gabriel Jesus has been cleared to face Tottenham after his £27m move from Palmeiras was formally completed on Thursday.
Fernando could return after injury but fellow midfielder Fernandinho remains suspended.
Tottenham defender Jan Vertonghen is set to miss the City clash with an ankle injury that is expected to rule him out for six weeks.
Midfielder Erik Lamela remains sidelined with a hip problem.
MOTD COMMENTATOR'S NOTES
Guy Mowbray: "Three in defence with full-backs pushed forward - and a bang in-form striker wearing number 10.
"That was Everton last week and could be Spurs this week, potentially posing another big problem for Manchester City.