Nuno Espirito Santo takes charge of his first game since being appointed Tottenham's new boss in their trip to Leyton Orient.
The League Two side have played two pre-season friendlies already, suffering a defeat by Dundee before holding Premier League outfit West Ham to a goalless draw in the week.
Now it is Spurs' turn to begin their pre-season matches and hand Portuguese boss Nuno his first look at his squad - without the likes of Harry Kane - in a match situation.
Follow Sportsmail's MAX MATHEWS for live coverage of the friendly from Brisbane Road, including build-up, team news and scoreline, as well as updates from Wolves' trip to Crewe and Brentford's match at Wimbledon.