Back after 13 months on the sidelines with a hip injury, Lamela came off the bench on 77 minutes and 80 seconds later, played in Harry Kane to rifle home for 2-1.
That proved the highlight of the night though as we laid siege to the home goal in the second half without finding an equaliser.
Our best chances fell to Christian Eriksen and Fernando Llorente but somehow that second goal proved elusive.
In the end, we paid for conceding two goals in the first half, taken well by Jamie Vardy and Riyad Mahrez.
Mauricio Pochettino made four changes to the team that started against West Brom on Saturday.