Mauricio Pochettino reported in his pre-match press conference at the Allianz Stadium that Toby Alderweireld, Juan Foyth and Kyle Walker-Peters hadn't flown out to Italy and remained at Hotspur Way to work.
Asked further about Toby, Mauricio said: "He had a massive injury and from day one, we designed a plan to provide him with the best tools to recover as soon as possible and to be stronger than before.
"He has started to work with the team and it's our judgement that he needs to build his fitness.
"We were lucky to have the replay against Newport for him to start to feel the competition.