The skipper reached the milestone in Saturday’s 2-1 win at Stoke.
Hugo, 31, also captain of France, signed from Lyon in August, 2012.
He made his Premier League debut in a 2-0 win against Villa on 7 October, 2012 before taking over the number one spot from Brad Friedel for the derby at Arsenal in November, 2012.
Since then, Hugo has started 199 of 211 matches in the Premier League.
"I can be proud of that and hopefully there will be many more in the future,” said Hugo at Stoke.
Appearances for Spurs in the Premier League era, starting from 1992-93.