Tottenham will host Rostov or Maccabi Haifa in the Europa League play-off if they beat Shkendija in the third-round qualifier.
Spurs will face the Macedonian side on Thursday after they beat nine-man Lokomotiv Plovdiv 2-1 to progress from the second round of qualifying.
If they win, they will play the Russian or Israeli side at the Tottenham Hotspur Stadium on 1 October.
Next week's trip to Macedonia comes at a busy time for Jose Mourinho's Spurs.
They have a Premier League game against Southampton on Sunday, an EFL Cup match against Leyton Orient on Tuesday and the journey to North Macedonia two days later.