FA Cup winners Arsenal will face League of Ireland side Dundalk, Rapid Vienna and Molde in Group B of the 2020-21 Europa League.
Tottenham have been drawn alongside Bulgarian champions Ludogorets, LASK and Royal Antwerp in Group J.
Leicester City will face Braga, AEK Athens and Ukrainian side Zorya Luhansk in Group G.
Scottish champions Celtic face a tough task in Group H as they take on AC Milan, Lille and Sparta Prague.
Rangers are in Group D alongside Benfica, Standard Liege and Lech Poznan.
The first three group matches will take place on successive Thursdays from 22 October.