Chelsea defender Thiago Silva, who announced on Monday he will leave the club at the end of the season, is ruled out by a groin injury.
Axel Disasi will be assessed, while this game may come too soon for Levi Colwill and Christopher Nkunku.
Tottenham forward Timo Werner will miss the remainder of the season because of a hamstring issue.
Ben Davies' campaign is also probably over after he hurt his calf but Oliver Skipp is set to return to contention.
Head-to-head
- Chelsea have lost only one of their past 10 Premier League fixtures versus Spurs (W7, D2).