Chelsea will be without Mateo Kovacic on Sunday because of a knee injury.
Left-back Marcos Alonso will also be missing; head coach Thomas Tuchel said he "is not training as he tries to finalise his transfer (to Barcelona)".
Tottenham could hand a debut to £60m summer signing Richarlison after his return from suspension.
They will be without defender Clement Lenglet, who has slight tightness in his adductor muscle, and Oliver Skipp, who has a foot injury.
CHRIS SUTTON'S PREDICTION
Chelsea love playing Spurs - they beat them four times last season, and Tottenham have only beaten them once in the league at Stamford Bridge since February 1990.