Chelsea head coach Thomas Tuchel has confirmed he remains without defenders Trevoh Chalobah, Ben Chilwell, Andreas Christensen and Reece James.
Goalkeeper Edouard Mendy remains on international duty with Senegal at the Africa Cup of Nations.
Tottenham defender Eric Dier is fit again after three weeks out with a muscular injury.
Son Heung-min and Cristian Romero are likely to return after the international break.
LAWRO'S PREDICTION
I really do think Chelsea have to just deal with their busy schedule and get on with it.
The Blues are not in good form but it probably helps them that they are playing Tottenham, firstly because they kept them at arm's length in both their Carabao Cup semi-final games recently, and also because this will be feisty and that should bring the best out of Tuchel's team.