For the first time in the Champions League era, the round of 16 consists solely of clubs from Europe's big five leagues -- England, Spain, France, Germany and Italy -- and the draw for the knockout phase has thrown up some heavyweight collisions involving holders Liverpool and La Liga giants Real Madrid and Barcelona.
Having won their sixth European crown in Madrid last season, Liverpool must return to the scene of their triumph for a tough encounter with Diego Simeone's Atletico Madrid, while Real Madrid's reward for finishing second in their group is a clash with Pep Guardiola's Manchester City.